IRGM

Universal Cellular Machinery · Small GTPase Switching & Nucleotide Exchange

How can cellular recycling help fight bacteria?

IRGM makes a protein that helps trigger autophagy in response to certain infections. The process can enclose and destroy invading material as part of the cell's defense.

Common Gene Name: immunity related GTPase M
NCBI Gene ID: 345611
Chromosome: 5

Clinical Evidence Status

Clinical utility not established here

These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.

Answer Sources

NCBI Gene — 345611
MedlinePlus Genetics — irgm

Explore supporting evidence (1 records)

Condition or drug	Evidence	Grade / status	Context	Source
Crohn disease	MedlinePlus related condition	Association type varies; no grade assigned here		View source 2017-12

Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.

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