KCNJ11
Nervous System · Neuronal Excitability & Ion Flux
How does a potassium channel help control insulin release?
KCNJ11 makes a channel component that partners with the ABCC8 product in pancreatic beta cells. The channel links the cell's energy state with signals controlling insulin secretion.
- Common Gene Name
- potassium inwardly rectifying channel subfamily J member 11
- NCBI Gene ID
- 3767
- Chromosome
- 11
Clinical Evidence Status
Established disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (7 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| monogenic diabetes | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2023-01-05 |
| hyperinsulinemic hypoglycemia, familial, 2 | ClinGen gene-disease validity | Definitive | Autosomal recessive | View source 2026-03-03 |
| hyperinsulinemic hypoglycemia, familial, 2 | ClinGen gene-disease validity | Limited | Autosomal dominant | View source 2026-06-02 |
| Congenital hyperinsulinism | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2026-01 | |
| Permanent neonatal diabetes mellitus | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2026-01 | |
| Gestational diabetes | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2026-01 | |
| Maturity-onset diabetes of the young | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2026-01 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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