LRP5
Musculoskeletal System · Bone Remodeling
How does LRP5 help cells respond to growth signals?
LRP5 makes a co-receptor that participates in Wnt signaling. By working with other receptors, it helps translate outside signals into developmental and tissue-maintenance programs.
- Common Gene Name
- LDL receptor related protein 5
- NCBI Gene ID
- 4041
- Chromosome
- 11
Clinical Evidence Status
Established disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (6 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| LRP5-related exudative vitreoretinopathy | ClinGen gene-disease validity | Definitive | Autosomal recessive | View source 2023-03-02 |
| polycystic liver disease 4 with or without kidney cysts | ClinGen gene-disease validity | Limited | Autosomal dominant | View source 2023-11-13 |
| Familial exudative vitreoretinopathy | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2024-02 | |
| Anophthalmia/Microphthalmia | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2024-02 | |
| Osteoporosis-pseudoglioma syndrome | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2024-02 | |
| Juvenile primary osteoporosis | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2024-02 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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