LRRK2
Universal Cellular Machinery · Phosphorylation & Kinase Signaling Cascades
Does an LRRK2 finding make Parkinson's disease certain?
LRRK2 encodes a protein involved in signaling and other cellular functions in the brain and elsewhere. The significance and penetrance of a finding depend on the specific variant, so even a risk-related result is not a guaranteed diagnosis.
- Common Gene Name
- leucine rich repeat kinase 2
- NCBI Gene ID
- 120892
- Chromosome
- 12
Clinical Evidence Status
Established disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (2 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| Parkinson disease | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2021-05-03 |
| Crohn disease | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2012-05 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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