MDM2

Universal Cellular Machinery · Cell Cycle Control & Mitotic Division

How does MDM2 regulate the tumor-suppressor protein p53?

MDM2 makes an enzyme that can tag p53 for degradation. This is part of a feedback system controlling growth responses, which can become disrupted when MDM2 activity is excessive.

Common Gene Name: MDM2 proto-oncogene
NCBI Gene ID: 4193
Chromosome: 12

Clinical Evidence Status

Clinical utility not established here

These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.

Answer Sources

NCBI Gene — 4193

Explore supporting evidence (0 records)

No additional curated records were matched in this dataset. This does not mean that no evidence exists.

Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.

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