MFN2
Universal Cellular Machinery · Mitochondrial Biogenesis & Dynamics
Why does mitochondrial shape matter to nerves and muscles?
MFN2 encodes mitofusin 2, a protein that helps organize mitochondrial shape and interactions. Maintaining these dynamic energy-producing structures supports cells with demanding transport and energy needs.
- Common Gene Name
- mitofusin 2
- NCBI Gene ID
- 9927
- Chromosome
- 1
Clinical Evidence Status
Established disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (3 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| multiple symmetric lipomatosis with partial lipodystrophy | ClinGen gene-disease validity | Definitive | Autosomal recessive | View source 2025-09-10 |
| Charcot-Marie-Tooth disease type 2A2 | ClinGen gene-disease validity | Definitive | Semidominant | View source 2026-08-08 |
| Charcot-Marie-Tooth disease | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2018-10 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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