MLH1
Universal Cellular Machinery · DNA Damage Repair & Genomic Integrity
How does MLH1 help correct mistakes made while DNA is copied?
MLH1 makes a mismatch-repair protein that pairs with PMS2. Their complex coordinates repair after copying errors are recognized.
- Common Gene Name
- mutL homolog 1
- NCBI Gene ID
- 4292
- Chromosome
- 3
Clinical Evidence Status
Actionability report availableEstablished disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (7 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| Lynch syndrome | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2022-06-20 |
| mismatch repair cancer syndrome 1 | ClinGen gene-disease validity | Definitive | Autosomal recessive | View source 2018-10-09 |
| hereditary breast carcinoma | ClinGen gene-disease validity | Refuted | Autosomal dominant | View source 2023-12-21 |
| Constitutional mismatch repair deficiency syndrome | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2025-05 | |
| Mismatch repair cancer syndrome (MMRCS) | ClinGen clinical actionability | Scored report; not a validity grade | Adult | View source 2022-12-06 |
| Lynch Syndrome | ClinGen clinical actionability | Scored report; not a validity grade | Adult | View source 2023-06-28 |
| Mismatch repair cancer syndrome (MMRCS) | ClinGen clinical actionability | Scored report; not a validity grade | Pediatric | View source 2024-03-24 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
← Back to Universal Cellular Machinery