MPL
Hematologic System · Hematopoiesis, Erythropoiesis & Iron Homeostasis
What connects MPL to my platelet count?
MPL makes the receptor for thrombopoietin, a signal supporting cells that produce platelets. Different disruptions can alter blood-cell production, but a DNA finding is not a substitute for a blood count.
- Common Gene Name
- MPL proto-oncogene, thrombopoietin receptor
- NCBI Gene ID
- 4352
- Chromosome
- 1
Clinical Evidence Status
Established disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (4 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| thrombocythemia 2 | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2020-07-22 |
| congenital amegakaryocytic thrombocytopenia 1 | ClinGen gene-disease validity | Definitive | Autosomal recessive | View source 2020-07-22 |
| Primary myelofibrosis | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2014-09 | |
| Essential thrombocythemia | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2014-09 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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