MSH6
Universal Cellular Machinery · DNA Damage Repair & Genomic Integrity
Why are MSH6 and MSH2 often listed together in DNA repair?
MSH6 makes a protein that pairs with MSH2 to identify selected DNA-copying errors. Their partnership helps initiate mismatch repair and preserve sequence accuracy.
- Common Gene Name
- mutS homolog 6
- NCBI Gene ID
- 2956
- Chromosome
- 2
Clinical Evidence Status
Actionability report availableEstablished disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (7 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| mismatch repair cancer syndrome 1 | ClinGen gene-disease validity | Definitive | Autosomal recessive | View source 2018-10-09 |
| Lynch syndrome | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2023-07-05 |
| hereditary breast carcinoma | ClinGen gene-disease validity | Disputed | Autosomal dominant | View source 2023-12-21 |
| Constitutional mismatch repair deficiency syndrome | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2025-05 | |
| Mismatch repair cancer syndrome (MMRCS) | ClinGen clinical actionability | Scored report; not a validity grade | Adult | View source 2022-12-06 |
| Lynch Syndrome | ClinGen clinical actionability | Scored report; not a validity grade | Adult | View source 2023-06-28 |
| Mismatch repair cancer syndrome (MMRCS) | ClinGen clinical actionability | Scored report; not a validity grade | Pediatric | View source 2024-03-24 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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