MTRR
Metabolic System · Vitamin, Cofactor & One-Carbon Metabolism
Why does the homocysteine pathway need MTRR as well as MTR?
MTRR makes an enzyme that helps keep methionine synthase functioning. It supports the recycling machinery rather than independently proving whether someone's homocysteine level is high.
- Common Gene Name
- 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
- NCBI Gene ID
- 4552
- Chromosome
- 5
Clinical Evidence Status
Established disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (2 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| methylcobalamin deficiency type cblE | ClinGen gene-disease validity | Definitive | Autosomal recessive | View source 2021-07-02 |
| Homocystinuria | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2011-07 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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