MUTYH

Universal Cellular Machinery · DNA Damage Repair & Genomic Integrity

Why does it matter whether a MUTYH finding affects one or both gene copies?

MUTYH makes an enzyme used in repairing particular DNA-base errors. The inheritance pattern and number of pathogenic copies are central to interpreting associated polyposis risk, so an unspecified variant label is insufficient.

Common Gene Name
mutY DNA glycosylase
NCBI Gene ID
4595
Chromosome
1

Clinical Evidence Status

Actionability report availableEstablished disease relationship

These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.

Answer Sources

Explore supporting evidence (8 records)
Condition or drugEvidenceGrade / statusContextSource
familial ovarian cancerClinGen gene-disease validityDisputedAutosomal recessiveView source
2023-12-20
familial ovarian cancerClinGen gene-disease validityDisputedAutosomal dominantView source
2023-12-20
familial adenomatous polyposis 2ClinGen gene-disease validityDefinitiveAutosomal recessiveView source
2022-06-20
hereditary breast carcinomaClinGen gene-disease validityDisputedAutosomal recessiveView source
2023-12-21
colorectal cancerClinGen gene-disease validityDisputedAutosomal dominantView source
2023-03-24
hereditary breast carcinomaClinGen gene-disease validityRefutedAutosomal dominantView source
2023-12-21
MUTYH-associated polyposisMedlinePlus related conditionAssociation type varies; no grade assigned hereView source
2025-08
MUTYH-Associated PolyposisClinGen clinical actionabilityScored report; not a validity gradeAdultView source
2022-02-09

Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.

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