MYH11

Cardiovascular System · Vascular Smooth Muscle Contraction

Why would MYH11 appear on an aortic-disease gene panel?

MYH11 produces part of the motor that contracts smooth muscle in vessel walls. Certain pathogenic variants are linked to inherited thoracic aortic aneurysm and dissection, making confirmed results relevant to a matching clinical evaluation.

Common Gene Name
myosin heavy chain 11
NCBI Gene ID
4629
Chromosome
16

Clinical Evidence Status

Actionability report availableEstablished disease relationship

These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.

Answer Sources

Explore supporting evidence (8 records)
Condition or drugEvidenceGrade / statusContextSource
congenital heart diseaseClinGen gene-disease validityLimitedAutosomal dominantView source
2024-10-15
familial thoracic aortic aneurysm and aortic dissectionClinGen gene-disease validityDefinitiveAutosomal dominantView source
2016-07-03
Familial thoracic aortic aneurysm and dissectionMedlinePlus related conditionAssociation type varies; no grade assigned hereView source
2013-11
Intestinal pseudo-obstructionMedlinePlus related conditionAssociation type varies; no grade assigned hereView source
2013-11
Core binding factor acute myeloid leukemiaMedlinePlus related conditionAssociation type varies; no grade assigned hereView source
2013-11
Megacystis-microcolon-intestinal hypoperistalsis syndromeMedlinePlus related conditionAssociation type varies; no grade assigned hereView source
2013-11
Familial thoracic aortic aneurysms and dissections (FTAAD)ClinGen clinical actionabilityScored report; not a validity gradeAdultView source
2021-08-16
Familial thoracic aortic aneurysms and dissections (FTAAD)ClinGen clinical actionabilityScored report; not a validity gradePediatricView source
2022-02-09

Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.

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