NKX2-5
Cardiovascular System · Cardiac Electrophysiology & Conduction
Why can NKX2-5 affect both heart structure and rhythm?
NKX2-5 controls genes used as the heart develops. Certain disease-causing variants can affect the heart's formation and electrical conduction, explaining why the same gene can appear in both kinds of evaluation.
- Common Gene Name
- NK2 homeobox 5
- NCBI Gene ID
- 1482
- Chromosome
- 5
Clinical Evidence Status
Established disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (1 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| NKX2.5-related congenital, conduction and myopathic heart disease | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2024-11-07 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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