NOD2
Immune System · Pattern Recognition & Innate Priming
Does a NOD2 finding automatically mean Crohn's disease?
NOD2 makes an immune sensor active in defense cells and parts of the intestinal lining. Some findings are relevant to disease susceptibility, but a variant alone cannot establish the cause of digestive symptoms.
- Common Gene Name
- nucleotide binding oligomerization domain containing 2
- NCBI Gene ID
- 64127
- Chromosome
- 16
Clinical Evidence Status
Established disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (3 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| Blau syndrome | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2020-10-07 |
| Crohn disease | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2017-12 | |
| Yao syndrome | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2017-12 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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