NPHS1
Renal System · Glomerular Filtration Barrier
What helps keep important proteins from leaking through kidney filters?
NPHS1 makes nephrin, a protein positioned between specialized kidney cells called podocytes. Nephrin contributes to the slit diaphragm, an essential part of the filtration barrier.
- Common Gene Name
- NPHS1 adhesion molecule, nephrin
- NCBI Gene ID
- 4868
- Chromosome
- 19
Clinical Evidence Status
Established disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (2 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| congenital nephrotic syndrome, Finnish type | ClinGen gene-disease validity | Definitive | Autosomal recessive | View source 2022-01-10 |
| Congenital nephrotic syndrome | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2016-07 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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