NPM1

Universal Cellular Machinery · Ribosome Biogenesis & Translation

What does nucleophosmin do inside the nucleus?

NPM1 makes a protein concentrated in the nucleolus that also moves between nuclear and cytoplasmic compartments. It participates in several processes, including protein-production machinery and cell-cycle regulation.

Common Gene Name
nucleophosmin 1
NCBI Gene ID
4869
Chromosome
5

Clinical Evidence Status

Disease evidence limited or conflictingTumor or drug-label biomarker context

These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.

Answer Sources

Explore supporting evidence (7 records)
Condition or drugEvidenceGrade / statusContextSource
bone marrow failure syndromeClinGen gene-disease validityLimitedAutosomal dominantView source
2025-04-08
Acute promyelocytic leukemiaMedlinePlus related conditionAssociation type varies; no grade assigned hereView source
2013-12
Cytogenetically normal acute myeloid leukemiaMedlinePlus related conditionAssociation type varies; no grade assigned hereView source
2013-12
Midostaurin (2)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Venetoclax (7)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Revumenib (1)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Ziftomenib (1)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source

Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.

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