NR3C2
Renal System · Renin-Angiotensin-Aldosterone System
Why can a hormone receptor affect both sodium and blood pressure?
NR3C2 makes the mineralocorticoid receptor, which responds to hormones involved in sodium regulation. Changes in sodium handling influence fluid balance and therefore can affect blood pressure.
- Common Gene Name
- nuclear receptor subfamily 3 group C member 2
- NCBI Gene ID
- 4306
- Chromosome
- 4
Clinical Evidence Status
Established disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (3 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| pseudohyperaldosteronism type 2 | ClinGen gene-disease validity | Limited | Autosomal dominant | View source 2021-07-15 |
| autosomal dominant pseudohypoaldosteronism type 1 | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2021-07-15 |
| Pseudohypoaldosteronism type 1 | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2011-12 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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