NUDT15
Universal Cellular Machinery · Core Enzymatic Catalysis & Cofactor Chemistry
Why can NUDT15 matter for thiopurine side effects?
NUDT15 makes an enzyme involved in limiting the buildup of active thiopurine-related compounds. Reduced function can affect toxicity risk, requiring medication-specific clinical interpretation rather than an independent dose change.
- Common Gene Name
- nudix hydrolase 15
- NCBI Gene ID
- 55270
- Chromosome
- 13
Clinical Evidence Status
Drug-response evidence availableTumor or drug-label biomarker context
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (6 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| Azathioprine | FDA pharmacogenetics | Management recommendation | Drug-specific subgroup | View source |
| Mercaptopurine | FDA pharmacogenetics | Management recommendation | Drug-specific subgroup | View source |
| Thioguanine | FDA pharmacogenetics | Management recommendation | Drug-specific subgroup | View source |
| Azathioprine (2) | FDA labeling biomarker | Label mentions biomarker; actionability not inferred | Rheumatology | View source |
| Mercaptopurine (2) | FDA labeling biomarker | Label mentions biomarker; actionability not inferred | Oncology | View source |
| Thioguanine (2) | FDA labeling biomarker | Label mentions biomarker; actionability not inferred | Oncology | View source |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
← Back to Universal Cellular Machinery