OPTN
Universal Cellular Machinery · Autophagy & Lysosomal Degradation
What does optineurin do in the movement of materials inside cells?
OPTN encodes optineurin, a protein involved in membrane traffic and cellular signaling. These housekeeping roles help explain why it is studied in both eye and nervous-system conditions.
- Common Gene Name
- optineurin
- NCBI Gene ID
- 10133
- Chromosome
- 10
Clinical Evidence Status
Established disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (2 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| amyotrophic lateral sclerosis type 12 | ClinGen gene-disease validity | Definitive | Semidominant | View source 2022-05-10 |
| glaucoma, normal tension, susceptibility to | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2022-11-17 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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