PALB2
Universal Cellular Machinery · DNA Damage Repair & Genomic Integrity
How does PALB2 help the BRCA2 repair protein do its job?
PALB2 makes a partner protein that helps BRCA2 remain properly positioned in the nucleus. This partnership supports DNA repair, connecting PALB2 to inherited cancer-predisposition evaluation when a pathogenic variant is confirmed.
- Common Gene Name
- partner and localizer of BRCA2
- NCBI Gene ID
- 79728
- Chromosome
- 16
Clinical Evidence Status
Actionability report availableEstablished disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (5 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| Fanconi anemia complementation group N | ClinGen gene-disease validity | Definitive | Autosomal recessive | View source 2019-08-18 |
| PALB2-related cancer predisposition | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2024-08-29 |
| Fanconi Anemia | ClinGen clinical actionability | Scored report; not a validity grade | Adult | View source 2025-09-23 |
| PALB2-related cancers | ClinGen clinical actionability | Scored report; not a validity grade | Adult | View source 2025-09-19 |
| Fanconi Anemia | ClinGen clinical actionability | Scored report; not a validity grade | Pediatric | View source 2025-09-23 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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