PAX8

Endocrine System · Thyroid Hormone Synthesis & Action

What role does PAX8 play in organ development?

PAX8 makes a protein that binds DNA and regulates other genes. This helps cells follow the developmental programs needed to form tissues and maintain their specialized functions.

Common Gene Name: paired box 8
NCBI Gene ID: 7849
Chromosome: 2

Clinical Evidence Status

Clinical utility not established here

These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.

Answer Sources

NCBI Gene — 7849
MedlinePlus Genetics — pax8

Explore supporting evidence (1 records)

Condition or drug	Evidence	Grade / status	Context	Source
Congenital hypothyroidism	MedlinePlus related condition	Association type varies; no grade assigned here		View source 2015-09

Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.

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