PIK3CA

Universal Cellular Machinery · Phosphorylation & Kinase Signaling Cascades

How can a PIK3CA change affect growth in only some tissues?

PIK3CA makes the catalytic component of a growth-signaling enzyme called PI3K. Changes acquired after conception can be present in only a subset of cells, making the sampled tissue important to interpretation.

Common Gene Name
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
NCBI Gene ID
5290
Chromosome
3

Clinical Evidence Status

Disease evidence limited or conflictingTumor or drug-label biomarker context

These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.

Answer Sources

Explore supporting evidence (16 records)
Condition or drugEvidenceGrade / statusContextSource
hereditary breast carcinomaClinGen gene-disease validityRefutedAutosomal dominantView source
2023-12-21
familial ovarian cancerClinGen gene-disease validityNo Known Disease RelationshipAutosomal dominantView source
2017-02-08
Bladder cancerMedlinePlus related conditionAssociation type varies; no grade assigned hereView source
2020-02
Cowden syndromeMedlinePlus related conditionAssociation type varies; no grade assigned hereView source
2020-02
Klippel-Trenaunay syndromeMedlinePlus related conditionAssociation type varies; no grade assigned hereView source
2020-02
Epidermal nevusMedlinePlus related conditionAssociation type varies; no grade assigned hereView source
2020-02
Megalencephaly-capillary malformation syndromeMedlinePlus related conditionAssociation type varies; no grade assigned hereView source
2020-02
Head and neck squamous cell carcinomaMedlinePlus related conditionAssociation type varies; no grade assigned hereView source
2020-02
Ovarian cancerMedlinePlus related conditionAssociation type varies; no grade assigned hereView source
2020-02
Lung cancerMedlinePlus related conditionAssociation type varies; no grade assigned hereView source
2020-02
CholangiocarcinomaMedlinePlus related conditionAssociation type varies; no grade assigned hereView source
2020-02
Alpelisib (3)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Capivasertib (4)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Inavolisib (3)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Palbociclib (3)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source
Fam-Trastuzumab Deruxtecan-nxki (3)FDA labeling biomarkerLabel mentions biomarker; actionability not inferredOncologyView source

Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.

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