PKD2
Nervous System · Neuronal Excitability & Ion Flux
How is PKD2 related to the other major polycystic-kidney gene?
PKD2 makes polycystin-2, a channel-related protein that works with polycystin-1. Their interacting roles help explain why changes in either gene can be relevant to similar kidney-disease evaluations.
- Common Gene Name
- polycystin 2, transient receptor potential cation channel
- NCBI Gene ID
- 5311
- Chromosome
- 4
Clinical Evidence Status
Actionability report availableEstablished disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (3 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| autosomal dominant polycystic kidney disease | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2023-12-08 |
| Polycystic kidney disease | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2006-06 | |
| Autosomal Dominant Polycystic Kidney Disease | ClinGen clinical actionability | Scored report; not a validity grade | Adult | View source 2022-02-09 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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