PLA2G6
Universal Cellular Machinery · Phosphoinositide & Lipid Second Messenger Signaling
Why is phospholipid recycling important for cells?
PLA2G6 encodes an enzyme that breaks down selected membrane fats. This helps regulate lipid composition and maintain the integrity of cellular membranes.
- Common Gene Name
- phospholipase A2 group VI
- NCBI Gene ID
- 8398
- Chromosome
- 22
Clinical Evidence Status
Established disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (3 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| PLA2G6-associated neurodegeneration | ClinGen gene-disease validity | Definitive | Autosomal recessive | View source 2024-03-21 |
| Infantile neuroaxonal dystrophy | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2012-09 | |
| Melanoma | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2012-09 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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