PMP22

Nervous System · Myelination & Glial Trophic Support

What helps peripheral nerves carry signals efficiently?

PMP22 encodes a component of myelin, the insulating material around peripheral nerves. Proper myelin supports communication between the brain, spinal cord, muscles, and sensory tissues.

Common Gene Name
peripheral myelin protein 22
NCBI Gene ID
5376
Chromosome
17

Clinical Evidence Status

Actionability report availableEstablished disease relationship

These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.

Answer Sources

Explore supporting evidence (8 records)
Condition or drugEvidenceGrade / statusContextSource
Charcot-Marie-Tooth disease type 1AClinGen gene-disease validityDefinitiveAutosomal dominantView source
2022-10-10
hereditary neuropathy with liability to pressure palsiesClinGen gene-disease validityDefinitiveAutosomal dominantView source
2024-07-08
Charcot-Marie-Tooth diseaseMedlinePlus related conditionAssociation type varies; no grade assigned hereView source
2018-10
Yuan-Harel-Lupski syndromeMedlinePlus related conditionAssociation type varies; no grade assigned hereView source
2018-10
Hereditary Neuropathy with Liability to Pressure PalsiesClinGen clinical actionabilityScored report; not a validity gradeAdultView source
2024-10-29
Charcot - Marie - Tooth Disease, Type 1ClinGen clinical actionabilityScored report; not a validity gradeAdultView source
2024-08-16
Hereditary Neuropathy with Liability to Pressure PalsiesClinGen clinical actionabilityScored report; not a validity gradePediatricView source
2024-10-29
Charcot - Marie - Tooth Disease, Type 1ClinGen clinical actionabilityScored report; not a validity gradePediatricView source
2024-08-16

Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.

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