PMS2
Universal Cellular Machinery · DNA Damage Repair & Genomic Integrity
What is PMS2's job after a DNA-copying error is found?
PMS2 makes a mismatch-repair protein that works with MLH1. Their complex coordinates correction of the error, helping protect the accuracy of DNA passed to new cells.
- Common Gene Name
- PMS1 homolog 2, mismatch repair system component
- NCBI Gene ID
- 5395
- Chromosome
- 7
Clinical Evidence Status
Actionability report availableEstablished disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (7 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| Lynch syndrome | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2022-12-30 |
| hereditary breast carcinoma | ClinGen gene-disease validity | Disputed | Autosomal dominant | View source 2023-12-21 |
| mismatch repair cancer syndrome 1 | ClinGen gene-disease validity | Definitive | Autosomal recessive | View source 2022-12-30 |
| Constitutional mismatch repair deficiency syndrome | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2025-05 | |
| Mismatch repair cancer syndrome (MMRCS) | ClinGen clinical actionability | Scored report; not a validity grade | Adult | View source 2022-12-06 |
| Lynch Syndrome | ClinGen clinical actionability | Scored report; not a validity grade | Adult | View source 2023-06-28 |
| Mismatch repair cancer syndrome (MMRCS) | ClinGen clinical actionability | Scored report; not a validity grade | Pediatric | View source 2024-03-24 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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