PRKN
Universal Cellular Machinery · Autophagy & Lysosomal Degradation
How do cells label proteins that need to be removed?
PRKN encodes parkin, which helps attach ubiquitin tags to selected proteins. These tags direct cellular quality-control processes toward material that should be handled or degraded.
- Common Gene Name
- parkin RBR E3 ubiquitin protein ligase
- NCBI Gene ID
- 5071
- Chromosome
- 6
Clinical Evidence Status
Established disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (4 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| Parkinson disease | ClinGen gene-disease validity | Definitive | Autosomal recessive | View source 2023-01-18 |
| Ovarian cancer | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2012-05 | |
| Lung cancer | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2012-05 | |
| Leprosy | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2012-05 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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