PSEN1
Nervous System · Synaptic Plasticity & Neurotransmission
How is PSEN1 involved in processing other proteins?
PSEN1 makes the cutting component of the gamma-secretase complex. Certain pathogenic variants have inherited Alzheimer's-disease implications, but most interpretations require the exact change rather than the gene name alone.
- Common Gene Name
- presenilin 1
- NCBI Gene ID
- 5663
- Chromosome
- 14
Clinical Evidence Status
Disease evidence limited or conflicting
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (3 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| dilated cardiomyopathy 1U | ClinGen gene-disease validity | Disputed | Autosomal dominant | View source 2026-03-04 |
| Alzheimer disease | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2013-12 | |
| Hidradenitis suppurativa | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2013-12 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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