PSEN2
Nervous System · Synaptic Plasticity & Neurotransmission
Why is PSEN2 studied alongside amyloid precursor protein?
PSEN2 makes presenilin 2, which participates in processing proteins including APP. This connects it to amyloid-related biology, while disease interpretation depends on the particular variant and family context.
- Common Gene Name
- presenilin 2
- NCBI Gene ID
- 5664
- Chromosome
- 1
Clinical Evidence Status
Disease evidence limited or conflicting
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (2 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| dilated cardiomyopathy 1V | ClinGen gene-disease validity | Limited | Autosomal dominant | View source 2026-03-04 |
| Alzheimer disease | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2008-12 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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