PTEN
Universal Cellular Machinery · Dephosphorylation & Phosphatase Regulation
What normally prevents growth signals from becoming excessive?
PTEN makes an enzyme that restrains cellular growth-signaling pathways. Its tumor-suppressor activity helps coordinate cell size, survival, and division across many tissues.
- Common Gene Name
- phosphatase and tensin homolog
- NCBI Gene ID
- 5728
- Chromosome
- 10
Clinical Evidence Status
Actionability report availableEstablished disease relationshipTumor or drug-label biomarker context
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (13 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| PTEN hamartoma tumor syndrome | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2024-04-05 |
| Bladder cancer | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2015-05 | |
| Breast cancer | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2015-05 | |
| Cowden syndrome | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2015-05 | |
| Bannayan-Riley-Ruvalcaba syndrome | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2015-05 | |
| Head and neck squamous cell carcinoma | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2015-05 | |
| Prostate cancer | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2015-05 | |
| Lung cancer | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2015-05 | |
| Cholangiocarcinoma | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2015-05 | |
| Autism spectrum disorder | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2015-05 | |
| PTEN Hamartoma Tumor Syndrome - Cowden Syndrome | ClinGen clinical actionability | Scored report; not a validity grade | Adult | View source 2021-06-21 |
| PTEN Hamartoma Tumor Syndrome - Cowden Syndrome | ClinGen clinical actionability | Scored report; not a validity grade | Pediatric | View source 2022-02-09 |
| Capivasertib (5) | FDA labeling biomarker | Label mentions biomarker; actionability not inferred | Oncology | View source |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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