PTPN22
Universal Cellular Machinery · Dephosphorylation & Phosphatase Regulation
Does a PTPN22 association mean I have an autoimmune disease?
PTPN22 makes a phosphatase that helps regulate cellular signals, including immune signaling. An association can influence susceptibility without demonstrating that autoimmunity is present in an individual.
- Common Gene Name
- protein tyrosine phosphatase non-receptor type 22
- NCBI Gene ID
- 26191
- Chromosome
- 1
Clinical Evidence Status
Clinical utility not established here
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (10 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| Vitiligo | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2015-01 | |
| Idiopathic inflammatory myopathy | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2015-01 | |
| Juvenile idiopathic arthritis | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2015-01 | |
| Systemic scleroderma | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2015-01 | |
| Type 1 diabetes | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2015-01 | |
| Hashimoto thyroiditis | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2015-01 | |
| Graves disease | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2015-01 | |
| Autoimmune Addison disease | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2015-01 | |
| Systemic lupus erythematosus | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2015-01 | |
| Alopecia areata | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2015-01 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
← Back to Universal Cellular Machinery