RB1
Universal Cellular Machinery · Cell Cycle Control & Mitotic Division
How does RB1 stop cells from dividing at the wrong time?
RB1 makes pRB, which can prevent other proteins from initiating DNA replication. Controlling that prerequisite helps restrain cell division.
- Common Gene Name
- RB transcriptional corepressor 1
- NCBI Gene ID
- 5925
- Chromosome
- 13
Clinical Evidence Status
Actionability report availableEstablished disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (5 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| retinoblastoma | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2020-07-30 |
| Bladder cancer | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2009-04 | |
| Lung cancer | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2009-04 | |
| Cholangiocarcinoma | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2009-04 | |
| Retinoblastoma | ClinGen clinical actionability | Scored report; not a validity grade | Pediatric | View source 2022-02-09 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
← Back to Universal Cellular Machinery