RUNX1
Hematologic System · Hematopoiesis, Erythropoiesis & Iron Homeostasis
Why would RUNX1 be investigated in a family with blood-cell problems?
RUNX1 makes a DNA-binding regulator that controls genes involved in blood-cell development. A confirmed pathogenic finding can be relevant to inherited blood disorders, with interpretation depending on the family's clinical pattern.
- Common Gene Name
- RUNX family transcription factor 1
- NCBI Gene ID
- 861
- Chromosome
- 21
Clinical Evidence Status
Actionability report availableEstablished disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (7 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| hereditary thrombocytopenia and hematologic cancer predisposition syndrome | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2018-06-04 |
| Juvenile idiopathic arthritis | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2013-11 | |
| Core binding factor acute myeloid leukemia | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2013-11 | |
| Cytogenetically normal acute myeloid leukemia | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2013-11 | |
| Systemic mastocytosis | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2013-11 | |
| Hereditary thrombocytopenia and hematological cancer predisposition syndrome | ClinGen clinical actionability | Scored report; not a validity grade | Adult | View source 2022-02-09 |
| Hereditary thrombocytopenia and hematological cancer predisposition syndrome | ClinGen clinical actionability | Scored report; not a validity grade | Pediatric | View source 2022-02-09 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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