SCN9A
Sensory System · Nociception & Thermal Sensation
How can SCN9A influence the ability to feel pain?
SCN9A encodes the NaV1.7 sodium channel used by pain-sensing neurons. Specific pathogenic changes can alter signaling profoundly, while a typical consumer variant needs its own evidence-based interpretation.
- Common Gene Name
- sodium voltage-gated channel alpha subunit 9
- NCBI Gene ID
- 6335
- Chromosome
- 2
Clinical Evidence Status
Disease evidence limited or conflicting
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (7 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| epilepsy | ClinGen gene-disease validity | Refuted | Autosomal dominant | View source 2021-03-09 |
| Erythromelalgia | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2023-05 | |
| Hereditary sensory and autonomic neuropathy type II | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2023-05 | |
| Congenital insensitivity to pain | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2023-05 | |
| Paroxysmal extreme pain disorder | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2023-05 | |
| Small fiber neuropathy | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2023-05 | |
| Genetic epilepsy with febrile seizures plus | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2023-05 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
← Back to Sensory System