SDHD
Metabolic System · Mitochondrial Electron Transport & Oxidative Phosphorylation
What does SDHD do to keep an energy enzyme in place?
SDHD makes a subunit that anchors succinate dehydrogenase in the mitochondrial membrane. Its structural role allows the complex to participate in the cell's energy-conversion pathways.
- Common Gene Name
- succinate dehydrogenase complex subunit D
- NCBI Gene ID
- 6392
- Chromosome
- 11
Clinical Evidence Status
Actionability report availableEstablished disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (7 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| mitochondrial disease | ClinGen gene-disease validity | Limited | Autosomal recessive | View source 2022-04-04 |
| hereditary pheochromocytoma-paraganglioma | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2021-06-17 |
| Cowden syndrome | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2012-09 | |
| Hereditary paraganglioma-pheochromocytoma | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2012-09 | |
| Nonsyndromic paraganglioma | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2012-09 | |
| Gastrointestinal stromal tumor | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2012-09 | |
| Paragangliomas 1, 2, 3, 4, 5; Pheochromocytoma | ClinGen clinical actionability | Scored report; not a validity grade | Adult | View source 2022-02-09 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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