SERPINA1
Universal Cellular Machinery · Proteolysis & Protease Inhibition
Why does the body need alpha-1 antitrypsin to control other enzymes?
SERPINA1 makes alpha-1 antitrypsin, an inhibitor that restrains protein-digesting enzymes. This protection helps prevent normal enzyme activity from damaging tissues, particularly in the lungs.
- Common Gene Name
- serpin family A member 1
- NCBI Gene ID
- 5265
- Chromosome
- 14
Clinical Evidence Status
Actionability report available
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (3 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| Alpha-1 antitrypsin deficiency | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2009-08 | |
| Alpha-1 Antitrypsin Deficiency | ClinGen clinical actionability | Scored report; not a validity grade | Adult | View source 2024-12-20 |
| Alpha-1 Antitrypsin Deficiency | ClinGen clinical actionability | Scored report; not a validity grade | Pediatric | View source 2024-12-20 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
← Back to Universal Cellular Machinery