SHH
Integumentary System · Hair Follicle Morphogenesis & Keratin Assembly
How does SHH help a developing body form the right shape?
SHH produces Sonic Hedgehog, a signal that helps cells determine their developmental identity and position. It contributes to the formation of the brain, eyes, limbs, and other structures.
- Common Gene Name
- sonic hedgehog signaling molecule
- NCBI Gene ID
- 6469
- Chromosome
- 7
Clinical Evidence Status
Established disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (4 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| holoprosencephaly 3 | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2026-08-04 |
| Nonsyndromic holoprosencephaly | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2010-09 | |
| Anophthalmia/Microphthalmia | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2010-09 | |
| Coloboma | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2010-09 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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