SMAD3
Universal Cellular Machinery · Transcription Factor Regulation
How does a TGF-beta signal alter gene activity?
SMAD3 encodes a signaling protein that carries information from activated surface receptors toward the nucleus. It helps the outside environment influence the proteins a cell produces.
- Common Gene Name
- SMAD family member 3
- NCBI Gene ID
- 4088
- Chromosome
- 15
Clinical Evidence Status
Actionability report available
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (6 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| Familial thoracic aortic aneurysm and dissection | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2017-03 | |
| Loeys-Dietz syndrome | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2017-03 | |
| Loeys-Dietz Syndrome | ClinGen clinical actionability | Scored report; not a validity grade | Adult | View source 2021-08-24 |
| Familial thoracic aortic aneurysms and dissections (FTAAD) | ClinGen clinical actionability | Scored report; not a validity grade | Adult | View source 2021-08-16 |
| Familial thoracic aortic aneurysms and dissections (FTAAD) | ClinGen clinical actionability | Scored report; not a validity grade | Pediatric | View source 2022-02-09 |
| Loeys-Dietz Syndrome | ClinGen clinical actionability | Scored report; not a validity grade | Pediatric | View source 2022-02-09 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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