SMARCA4
Universal Cellular Machinery · Chromatin Remodeling & Epigenetic Regulation
How do cells loosen or tighten access to their DNA?
SMARCA4 makes BRG1, a component of SWI/SNF chromatin-remodeling complexes. These complexes change DNA packaging so selected genes become more or less accessible.
- Common Gene Name
- SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4
- NCBI Gene ID
- 6597
- Chromosome
- 19
Clinical Evidence Status
Actionability report availableEstablished disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (7 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| rhabdoid tumor predisposition syndrome 2 | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2018-06-29 |
| hereditary nonpolyposis colon cancer | ClinGen gene-disease validity | Limited | Autosomal dominant | View source 2017-05-08 |
| Coffin-Siris syndrome | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2025-06-08 |
| Lung cancer | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2018-04 | |
| Rhabdoid tumor predisposition syndrome | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2018-04 | |
| Rhabdoid tumor predisposition syndrome | ClinGen clinical actionability | Scored report; not a validity grade | Adult | View source 2022-02-09 |
| Rhabdoid tumor predisposition syndrome | ClinGen clinical actionability | Scored report; not a validity grade | Pediatric | View source 2022-02-09 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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