SNCA

Nervous System · Synaptic Plasticity & Neurotransmission

What does alpha-synuclein normally do near nerve endings?

SNCA encodes alpha-synuclein, a protein concentrated near the compartments that release neurotransmitters. Its location connects it to nerve communication, but a gene result does not directly measure abnormal protein deposits.

Common Gene Name
synuclein alpha
NCBI Gene ID
6622
Chromosome
4

Clinical Evidence Status

Established disease relationship

These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.

Answer Sources

Explore supporting evidence (3 records)
Condition or drugEvidenceGrade / statusContextSource
Parkinson diseaseClinGen gene-disease validityDefinitiveAutosomal dominantView source
2022-05-03
Multiple system atrophyMedlinePlus related conditionAssociation type varies; no grade assigned hereView source
2018-10
Dementia with Lewy bodiesMedlinePlus related conditionAssociation type varies; no grade assigned hereView source
2018-10

Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.

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