SOD1
Universal Cellular Machinery · Redox Homeostasis & Oxidative Stress Defense
What does SOD1 normally do with reactive oxygen molecules?
SOD1 encodes an enzyme that uses copper and zinc to process superoxide radicals. This normal protective role should be distinguished from the effects of particular pathogenic SOD1 variants associated with neurological disease.
- Common Gene Name
- superoxide dismutase 1
- NCBI Gene ID
- 6647
- Chromosome
- 21
Clinical Evidence Status
Established disease relationshipTumor or drug-label biomarker context
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (3 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| amyotrophic lateral sclerosis type 1 | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2021-07-13 |
| Amyotrophic lateral sclerosis | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2016-02 | |
| Tofersen | FDA labeling biomarker | Label mentions biomarker; actionability not inferred | Neurology | View source |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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