TPMT
Universal Cellular Machinery · Core Enzymatic Catalysis & Cofactor Chemistry
What does TPMT have to do with drugs such as azathioprine?
TPMT makes an enzyme that modifies thiopurine medicines and influences their metabolism. A confirmed enzyme-activity or genetic result can inform drug-specific prescribing, alongside other factors such as NUDT15 and monitoring.
- Common Gene Name
- thiopurine S-methyltransferase
- NCBI Gene ID
- 7172
- Chromosome
- 6
Clinical Evidence Status
Drug-response evidence availableTumor or drug-label biomarker context
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (8 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| Thiopurine S-methyltransferase deficiency | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2015-04 | |
| Azathioprine | FDA pharmacogenetics | Management recommendation | Drug-specific subgroup | View source |
| Mercaptopurine | FDA pharmacogenetics | Management recommendation | Drug-specific subgroup | View source |
| Thioguanine | FDA pharmacogenetics | Management recommendation | Drug-specific subgroup | View source |
| Azathioprine (1) | FDA labeling biomarker | Label mentions biomarker; actionability not inferred | Rheumatology | View source |
| Cisplatin | FDA labeling biomarker | Label mentions biomarker; actionability not inferred | Oncology | View source |
| Mercaptopurine (1) | FDA labeling biomarker | Label mentions biomarker; actionability not inferred | Oncology | View source |
| Thioguanine (1) | FDA labeling biomarker | Label mentions biomarker; actionability not inferred | Oncology | View source |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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