TREM2

Unclassified Loci · Unclassified Protein-Coding Locus

How does TREM2 help immune-related cells receive signals?

TREM2 makes a surface receptor that partners with the TYROBP protein. Together they relay signals that influence the activity of myeloid-lineage cells.

Common Gene Name: triggering receptor expressed on myeloid cells 2
NCBI Gene ID: 54209
Chromosome: 6

Clinical Evidence Status

Clinical utility not established here

These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.

Answer Sources

NCBI Gene — 54209
MedlinePlus Genetics — trem2

Explore supporting evidence (1 records)

Condition or drug	Evidence	Grade / status	Context	Source
Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy	MedlinePlus related condition	Association type varies; no grade assigned here		View source 2023-10

Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.

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