TSC1
Universal Cellular Machinery · Protein Scaffolding & Structural Architecture
How does hamartin help control cell size and growth?
TSC1 encodes hamartin, which partners with tuberin from TSC2. Together they help restrain growth signaling and prevent cells from increasing in size or number inappropriately.
- Common Gene Name
- TSC complex subunit 1
- NCBI Gene ID
- 7248
- Chromosome
- 9
Clinical Evidence Status
Actionability report available
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (5 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| Tuberous sclerosis complex | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2010-06 | |
| Lymphangioleiomyomatosis | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2010-06 | |
| Cholangiocarcinoma | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2010-06 | |
| Tuberous Sclerosis Complex (TSC) | ClinGen clinical actionability | Scored report; not a validity grade | Adult | View source 2023-02-21 |
| Tuberous Sclerosis Complex (TSC) | ClinGen clinical actionability | Scored report; not a validity grade | Pediatric | View source 2023-02-21 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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