TSC2
Universal Cellular Machinery · Protein Scaffolding & Structural Architecture
Why do TSC2 and TSC1 cause overlapping biological effects?
TSC2 makes tuberin, a partner of the TSC1 protein hamartin. Their shared growth-control function explains why disrupting either part can affect the same signaling system.
- Common Gene Name
- TSC complex subunit 2
- NCBI Gene ID
- 7249
- Chromosome
- 16
Clinical Evidence Status
Actionability report available
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (4 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| Tuberous sclerosis complex | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2010-06 | |
| Lymphangioleiomyomatosis | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2010-06 | |
| Tuberous Sclerosis Complex (TSC) | ClinGen clinical actionability | Scored report; not a validity grade | Adult | View source 2023-02-21 |
| Tuberous Sclerosis Complex (TSC) | ClinGen clinical actionability | Scored report; not a validity grade | Pediatric | View source 2023-02-21 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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