UBE3A
Universal Cellular Machinery · Ubiquitin-Proteasome Degradation
How do cells choose some proteins for disposal?
UBE3A makes an enzyme that attaches ubiquitin tags to selected proteins. The tags help direct proteins toward cellular quality-control and degradation systems.
- Common Gene Name
- ubiquitin protein ligase E3A
- NCBI Gene ID
- 7337
- Chromosome
- 15
Clinical Evidence Status
Established disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (1 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| Angelman syndrome | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2018-05-02 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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