VHL
Universal Cellular Machinery · Cell Cycle Control & Mitotic Division
How does VHL help cells remove proteins they no longer need?
VHL makes part of a complex that marks selected proteins for breakdown. This regulated removal supports normal cellular responses, including pathways connected to oxygen sensing.
- Common Gene Name
- von Hippel-Lindau tumor suppressor
- NCBI Gene ID
- 7428
- Chromosome
- 3
Clinical Evidence Status
Actionability report availableEstablished disease relationshipTumor or drug-label biomarker context
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (7 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| von Hippel-Lindau disease | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2020-05-14 |
| Von Hippel-Lindau syndrome | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2012-08 | |
| Nonsyndromic paraganglioma | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2012-08 | |
| Familial erythrocytosis | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2012-08 | |
| Von Hippel-Lindau Syndrome | ClinGen clinical actionability | Scored report; not a validity grade | Adult | View source 2022-02-21 |
| Von Hippel-Lindau Syndrome | ClinGen clinical actionability | Scored report; not a validity grade | Pediatric | View source 2022-03-17 |
| Belzutifan (3) | FDA labeling biomarker | Label mentions biomarker; actionability not inferred | Oncology | View source |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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