VKORC1
Hematologic System · Coagulation, Fibrin Formation & Fibrinolysis
Why is VKORC1 discussed with vitamin K and warfarin?
VKORC1 makes an enzyme that recycles vitamin K for the activation of clotting proteins. This pathway is relevant to warfarin response, but a genetic finding does not justify independently changing medication or vitamin K intake.
- Common Gene Name
- vitamin K epoxide reductase complex subunit 1
- NCBI Gene ID
- 79001
- Chromosome
- 16
Clinical Evidence Status
Drug-response evidence availableDisease evidence limited or conflictingTumor or drug-label biomarker context
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (5 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| vitamin K-dependent clotting factors, combined deficiency of, type 2 | ClinGen gene-disease validity | Moderate | Autosomal recessive | View source 2025-09-03 |
| Warfarin resistance | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2015-07 | |
| Warfarin sensitivity | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2015-07 | |
| Warfarin | FDA pharmacogenetics | Management recommendation | Drug-specific subgroup | View source |
| Warfarin (2) | FDA labeling biomarker | Label mentions biomarker; actionability not inferred | Hematology | View source |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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