WT1
Renal System · Glomerular Filtration Barrier
Why can WT1 connect kidney development with later kidney function?
WT1 controls genes needed to form the kidneys and gonads before birth. It also remains important in the kidney's filtering structures after birth.
- Common Gene Name
- WT1 transcription factor
- NCBI Gene ID
- 7490
- Chromosome
- 11
Clinical Evidence Status
Actionability report availableEstablished disease relationship
These labels describe available evidence about a gene. They do not classify your variant or recommend a treatment.
Answer Sources
Explore supporting evidence (10 records)
| Condition or drug | Evidence | Grade / status | Context | Source |
|---|---|---|---|---|
| Wilms tumor 1 | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2020-07-30 |
| Denys-Drash syndrome | ClinGen gene-disease validity | Definitive | Autosomal dominant | View source 2021-07-27 |
| 46,XX testicular disorder of sex development | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2018-09 | |
| WAGR syndrome | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2018-09 | |
| Frasier syndrome | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2018-09 | |
| Cytogenetically normal acute myeloid leukemia | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2018-09 | |
| Prostate cancer | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2018-09 | |
| Congenital nephrotic syndrome | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2018-09 | |
| Wilms tumor | MedlinePlus related condition | Association type varies; no grade assigned here | View source 2018-09 | |
| Wilms tumor | ClinGen clinical actionability | Scored report; not a validity grade | Pediatric | View source 2022-02-09 |
Source snapshot: 2026-09-09. Consumer text updated: 2026-09-10. Source dates describe the cited records, not a new clinical review.
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